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The chemical name isRN2-dimethylN2-propynylphenethylamine hydrochlorideIt is a white to near white crystalline powderfreely soluble in waterchloroformand methanoland has a molecular weight of 223.75The structural formula is as follows:
Selegiline is indicated for the treatment of Parkinson’s disease whichin most casesis a disease occurring after childbearing age.
Severe CNS toxicityserotonin syndromehas been reported in patients with the combination of tricyclic antidepressants and selegilineIn one patient receiving amitriptyline and selegiline this included hyperpyrexia and deathand another patient receiving protriptyline and selegiline experienced tremoragitationand restlessness followed by unresponsiveness and death two weeks after selegiline was added.
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